March 2024
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Research Updates
Advancing CANCollaborate's Mission: Workshop on Organoid Creation of Rare Cancers
In keeping with our mission of creating and facilitating collaboration, CANCollaborate hosted its first virtual workshop following from its origin at MIT’s April Workshop on rare cancers with a focus on appendiceal cancer. We are developing and optimizing collaborative models that bring together leading researchers and innovators. The models, which are designed to consolidate expertise, facilitate data and model sharing – will help ensure a more effective, time-sensitive and comprehensive approach to research.
This workshop was focused on the application and value of organoid models and the challenges of creating organoids for rare cancers, especially appendiceal cancers. We gathered our CANCollaborators from the MIT April Workshop in addition to new collaborators. Our goal was to facilitate the participant’s sharing of their perspectives and expertise, while providing support for and the fostering of new collaborative projects. The workshop included cancer biologists, physician researchers, technologists, industry partners and entrepreneurs.
A particular issue is the challenge in establishing organoids for the multiple types of appendiceal cancer, and especially the rarer forms of goblet cell adenocarcinomas and mucinous appendiceal cancers.
Challenges included -
· Accessing patient samples, a challenge that all rare cancers face as the density of patients at a particular facility can be low.
· Delays in the timely accession of fresh tissue that impacts organoid generation.
· Complexities in generating organoids from low grade tumors and mucinous tumors as the mucin is presumed to be inhibiting the growth of the organoids.
· Difficulties in generating organoids for highly heterogeneous tumors that will contain divergent biological behaviors.
Organoid Models can offer a high value to rare cancer research. They can enable a high-throughput screening of known cancer drugs and therapies, and can be used to identify a combinatorial approach to treatment or the re-purposing of known therapies that have not yet been identified as a potential therapy. In addition, organoids can offer a personalized view of a patient’s tumor allowing for better personalized treatment and the elimination of highly toxic treatments. They can also be used in developing an understanding of the basic biology of the disease.
Committed to finding a path forward, and to forge new collaborations, we identified the following collaborative projects -
· Use organoid models to develop a deeper understanding of clonality and how this impacts tumor progression and therapy resistance.
· Develop a high-throughput platform for new drug screening and drug repurposing, with a special focus on combinatorial therapies.
· Evaluate the generation of personalized organoids, using normal appendiceal tissues with CRISPR editing techniques to create models for difficult tumor types.
· Generate more comprehensive molecular characterization of appendiceal cancers with a commitment to data sharing.
· Direct certain organoid research toward immuno-oncology.
· Commit to the importance of sharing experimental protocols and cross-lab training.
· Share biosamples, especially from collaborators who experience a higher appendiceal caseload than others.
The consensus among participants was clear: collaboration is essential in the face of limited drug trials for appendiceal cancer, and more extensive testing is imperative.
Collaborations & Partnerships
Travera and CANCollaborate create access to Innovative Cancer Treatment
CANCollaborate is collaborating with Travera, a company whose mission is to bring hope to cancer patients who are running out of time and therapeutic options. Through its collaboration with CANCollaborate, Travera is offering its 2-day Rapid Therapy Selection™ test to patients with appendiceal cancers free of charge to help in their efforts to establish more treatment options and outcomes data.
Travera focuses on gastrointestinal and gynecologic cancers, assisting oncologists in selecting treatments for their patients using a revolutionary cancer therapy selection test that predicts which cancer drugs are most likely to be effective for each cancer patient, a potentially valuable tool for patients with rare or advanced diseases. Travera utilizes a disruptive single-cell measurement technology invented at MIT to measure the ex-vivo mass response of live tumor cells to candidate drugs. This novel technology has overcome the problems that have prevented the many previous generations of therapy selection tests from being effective in clinical practice.
CANCollaborate has created a network of appendiceal cancer CANCollaborators – oncologists, surgeons and researchers who will also have access to the Travera technologies through the Travera community of partnerships which include many patient advocacy and research groups.
We invite oncologists, surgeons, patients, and caregivers to hear more about this offering in a recorded webinar. Follow this link to learn more.
News
Joining the ARPA-H health innovation network
We are thrilled to announce that we’ve been selected as a spoke of the ARPA-H Investor Catalyst Hub network, a regional hub of ARPANET-H, a nationwide health innovation network launched by the Advanced Research Projects Agency for Health (ARPA-H).
Based in the Greater Boston area and managed by VentureWell, the Investor Catalyst Hub seeks to accelerate the commercialization of groundbreaking and accessible biomedical solutions. It utilizes an innovative hub-and-spoke model designed to reach a wide range of nonprofit organizations and Minority-Serving Institutions, with the ultimate aim of delivering scalable healthcare outcomes for all Americans.
As an Investor Catalyst Hub spoke, CANCollaborate gains access to potential funding and flexible contracting for faster award execution compared to traditional government contracts. Spoke membership also offers opportunities to provide input on ARPA-H challenge areas and priorities, along with access to valuable networking opportunities and a robust resource library.
Meetings & Conferences
Target Cancer Foundation - Think Tank on Advancing Precision Medicine in Rare Cancers
November 2023 - The Target Cancer Foundation Think Tank on Advancing Precision Medicine in Rare Cancers was held in Boston. Bringing together patients, patient advocates, foundations, clinicians, researchers and industry partners to highlight the challenges in rare cancers. Talks included a focus on tumor agnostic clinical trials and how these may offer important breakthroughs in rare cancers.
Advanced Cancer Therapies Meeting
February 2024 - CANCollaborate attended the Society for Surgical Oncology’s 2024 Advanced Cancer Therapies meeting held in San Juan Puerto Rico. We met many of our CANCollaborators in person. There were sessions detailing the current state of treatment for appendiceal cancer patients with presentations on optimizing CRS/HIPEC and the role of circulating tumor DNA (ctDNA), as well as research talks including studies looking at the single cell transcriptomics of appendiceal cancer as well as the metabolomics of appendiceal cancer. We saw the progress being made in identifying a biomarker for treatment response in other peritoneal diseases with work looking at the role of exosomes from the peritoneal space. The message was clear that there is a team of experts who are excited to work together to improve upon the care and treatment of patients with appendiceal cancer.
Rare Disease Day at the Broad Institute
March 2024 - The Broad Institute of MIT and Harvard in collaboration with The Termeer Foundation hosted the 9th annual Rare Disease Day event, “Climbing Ladders to Cures in Rare Disease Research''. Rare disease and rare cancer share many challenges that often stifle our progress in research - business models, regulatory requirements, traditional funding structures, and research that is often siloed. Like many of our rare disease colleagues we hope to change these research norms. You can view the event talks here.
New Appendiceal and Rare Cancer Publications
The future of precision cancer therapy might be to try everything Elie Dolgan 2024 featuring Alice Soragni
Cancer Is Striking More Young People, and Doctors Are Alarmed and Baffled Brianna Abbot 2024
Serum Tumor Markers and Outcomes in Patients With Appendiceal Adenocarcinoma JP Shen 2024
Doublet vs. Triplet Systemic Chemotherapy for High Grade Appendiceal Adenocarcinoma with Peritoneal Metastases Oliver Eng and Kiran Turaga 2023 (online 2024)
The Growing Problem of Early-Onset GI Cancers - ASCO GI Keynote Lecture with Kimmie Ng, MD, MPH 2024
Team Updates
We are hiring - summer internship
Firstly - a big thank you to Kyra Itskowitz for joining us this winter as our first intern and we’re looking forward to continuing our work with Kyra this summer.
If you’re interested in joining CANCollaborate for a remote summer internship please drop us a line here.
